Article
Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients.
Journal of hepatology - 1 Oct 2003
Rossi Laura, Leveri Michela, Gritti Chiara, De Silvestri Annalisa, Zavaglia Claudio, Sonzogni Laura, Silvestri Laura, Civardi Emilio, Mondelli Mario U, Silini Enrico M
Abstract excerpt
BACKGROUND/AIMS: Genetic polymorphisms of enzymes involved in hormone metabolism can influence hormonal activities and risk of hormone-dependent cancers. As progression of chronic hepatitis C and risk of liver cancer is higher in males than in females, we evaluated whether the polymorphisms of three enzymes participating in the pathway of estrogen and androgen biosynthesis and inactivation, 5alpha-reductase type...
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