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Article

Association of genetic polymorphisms in HSD17B1, HSD17B2 and SHBG genes with hepatocellular carcinoma risk.

Pathology oncology research : POR - 1 Jul 2014

Zhang Lu Shun, Yuan Fang, Guan Xuan, Li Juan, Liu Xin Lian, Sun Jing, Liu Bo, Ma Wei, Deng Feng Mei

Abstract excerpt

Genetic polymorphisms of enzymes involved in estrogen synthesizing/transporting can influence the risk of hormone-dependent diseases. The incidence rate and relative risk for hepatocellular carcinoma (HCC) are higher in men than in women. This study was conducted to explore the relationship of single nucleotide polymorphisms (SNPs) in 17 β-Hydroxysteroid dehydrogenases (HSD17B1 and HSD17B2) and sex...

Topics

Carcinoma, Hepatocellular
Case-Control Studies
Cohort Studies
Estradiol Dehydrogenases
Female
Follow-Up Studies
Genetic Predisposition to Disease
Genotype
Humans
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Neoplasm Staging

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Polymorphism, Single Nucleotide

Prognosis

Receptors, Cell Surface

Source

Identifiers

PMID: 24563232
DOI: 10.1007/s12253-014-9746-1

Genes

SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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