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Article

Functional Evaluation of ZNF350 Missense Genetic Variants Associated with Breast Cancer Susceptibility.

DNA and cell biology - 1 Jun 2018

Zhang Nasha, Lu Youhua, Liu Xijun, Yu Dianke, Lv Zheng, Yang Ming

Abstract excerpt

ZNF350, a BRCA1-interacting protein, could mediate BRCA1-induced sequence-specific transcriptional repression of several genes, including GADD45α. As a potential breast cancer susceptibility gene, single nucleotide polymorphisms (SNPs), especially missense SNPs, may influence the transcriptional repression of its target tumor suppressor genes and individuals' breast cancer risk. Using the gene-based...

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PMID: 29653063
DOI: 10.1089/dna.2018.4160

Genes

BRCA1

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