Article
Fine mapping of 14q24.1 breast cancer susceptibility locus.
Human genetics - 1 Mar 2012
Lee Phoebe, Fu Yi-Ping, Figueroa Jonine D, Prokunina-Olsson Ludmila, Gonzalez-Bosquet Jesus, Kraft Peter, Wang Zhaoming, Jacobs Kevin B, Yeager Meredith, Horner Marie-Josèphe, Hankinson Susan E, Hutchinson Amy, Chatterjee Nilanjan, Garcia-Closas Montserrat, Ziegler Regina G, Berg Christine D, Buys Saundra S, McCarty Catherine A, Feigelson Heather Spencer, Thun Michael J, Diver Ryan, Prentice Ross, Jackson Rebecca, Kooperberg Charles, Chlebowski Rowan, Lissowska Jolanta, Peplonska Beata, Brinton Louise A, Tucker Margaret, Fraumeni Joseph F, Hoover Robert N, Thomas Gilles, Hunter David J, Chanock Stephen J
Abstract excerpt
In the National Cancer Institute Cancer Genetic Markers of Susceptibility (CGEMS) genome-wide association study of breast cancer, a single nucleotide polymorphism (SNP) marker, rs999737, in the 14q24.1 interval, was associated with breast cancer risk. In order to fine map this region, we imputed a 3.93 MB region flanking rs999737 for Stages 1 and 2 of the CGEMS study (5,692 cases, 5,576 controls) using the...
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