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Article

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis.

Nature cell biology - 1 Mar 2011

Kuhlbrodt Kirsten, Janiesch Philipp Christoph, Kevei Éva, Segref Alexandra, Barikbin Roja, Hoppe Thorsten

Abstract excerpt

Protein ubiquitylation is a key post-translational control mechanism contributing to different physiological processes, such as signal transduction and ageing. The size and linkage of a ubiquitin chain, which determines whether a substrate is efficiently targeted for proteasomal degradation, is determined by the interplay between ubiquitylation and deubiquitylation. A conserved factor that orchestrates distinct...

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PMID: 21317884
DOI: 10.1038/ncb2200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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