Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model.

Cells - 19 Apr 2021

Kwa Mei Qi, Brandao Rafael, Phung Trong H, Ge Jianfeng, Scieri Giuseppe, Brakebusch Cord

Abstract excerpt

MRCKα is a ubiquitously expressed serine/threonine kinase involved in cell contraction and F-actin turnover, which is highly amplified in human breast cancer and part of a gene expression signature for bad prognosis. Nothing is known about the in vivo function of MRCKα. To explore MRCKα function in development and in breast cancer, we generated mice lacking a functional MRCKα gene. Mice were born close to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Depolymerizing Factors
Share to Antigens, Polyomavirus Transforming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Neoplasms, Animal

Share to Mammary Tumor Virus, Mouse

Share to Myotonin-Protein Kinase

Share to Polymerization

Share to Triple Negative Breast Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 33921698
DOI: 10.3390/cells10040942
PMCID: PMC8073694

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model.PMID 33921698Read ↗

Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletionSemantic proximity Read ↗

Maspin is not required for embryonic development or tumour suppressionSemantic proximity Read ↗

The Snf1-related kinase, Hunk, is essential for mammary tumor metastasisSemantic proximity Read ↗

The complexities of PKCα signaling in cancer.Semantic proximity Read ↗

CK2α is essential for embryonic morphogenesis.Semantic proximity Read ↗

Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.Semantic proximity Read ↗

Physiological expression of PI3K H1047R mutation reveals its anti-metastatic potential in ErbB2-driven breast cancer.Semantic proximity Read ↗

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.Semantic proximity Read ↗

Cells lacking IKKα show nuclear cyclin D1 overexpression and a neoplastic phenotype: role of IKKα as a tumor suppressor.Semantic proximity Read ↗

Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.Semantic proximity Read ↗

Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity.Semantic proximity Read ↗

HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.