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Article

Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity.

PloS one - 2 Feb 2011

Schleinitz Dorit, Klöting Nora, Böttcher Yvonne, Wolf Sara, Dietrich Kerstin, Tönjes Anke, Breitfeld Jana, Enigk Beate, Halbritter Jan, Körner Antje, Schön Michael R, Jenkner Jost, Tseng Yu-Hua, Lohmann Tobias, Dressler Miriam, Stumvoll Michael, Blüher Matthias, Kovacs Peter

Abstract excerpt

OBJECTIVE: Human bone morphogenetic protein receptor 2 (BMPR2) is essential for BMP signalling and may be involved in the regulation of adipogenesis. The BMPR2 locus has been suggested as target of recent selection in human populations. We hypothesized that BMPR2 might have a role in the pathophysiology of obesity. RESEARCH DESIGN AND METHODS: Evolutionary analyses (dN/dS, Fst, iHS) were conducted in vertebrates...

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Source

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Identifiers

PMID: 21311592
DOI: 10.1371/journal.pone.0016155
PMCID: PMC3032727

Genes

BMPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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