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Article

Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.

BMC medical genomics - 27 Dec 2012

Volckmar Anna-Lena, Bolze Florian, Jarick Ivonne, Knoll Nadja, Scherag André, Reinehr Thomas, Illig Thomas, Grallert Harald, Wichmann Heinz-Erich, Wiegand Susanna, Biebermann Heike, Krude Heiko, Fischer-Posovszky Pamela, Rief Winfried, Wabitsch Martin, Klingenspor Martin, Hebebrand Johannes, Hinney Anke

Abstract excerpt

BACKGROUND: The SH2B1 gene (Src-homology 2B adaptor protein 1 gene) is a solid candidate gene for obesity. Large scale GWAS studies depicted markers in the vicinity of the gene; animal models suggest a potential relevance for human body weight regulation. METHODS: We performed a mutation screen f...

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Identifiers

PMID: 23270367
DOI: 10.1186/1755-8794-5-65
PMCID: PMC3544595

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STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23270367-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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