Signatures of natural selection at the FTO (fat mass and obesity associated) locus in human populations.

doi:10.1371/journal.pone.0117093

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Article

Signatures of natural selection at the FTO (fat mass and obesity associated) locus in human populations.

PloS one - 1 Jan 2015

Liu Xuanshi, Weidle Kerstin, Schröck Kristin, Tönjes Anke, Schleinitz Dorit, Breitfeld Jana, Stumvoll Michael, Böttcher Yvonne, Schöneberg Torsten, Kovacs Peter

Abstract excerpt

BACKGROUND AND AIMS: Polymorphisms in the first intron of FTO have been robustly replicated for associations with obesity. In the Sorbs, a Slavic population resident in Germany, the strongest effect on body mass index (BMI) was found for a variant in the third intron of FTO (rs17818902). Since this may indicate population specific effects of FTO variants, we initiated studies testing FTO for signatures of...

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Identifiers

PMID: 25647475
DOI: 10.1371/journal.pone.0117093
PMCID: PMC4315420

Genes

FTO
TCF3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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