Article
Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity.
Diabetes - 1 Sept 2009
Böttcher Yvonne, Unbehauen Hanne, Klöting Nora, Ruschke Karen, Körner Antje, Schleinitz Dorit, Tönjes Anke, Enigk Beate, Wolf Sara, Dietrich Kerstin, Koriath Moritz, Scholz Gerhard Harry, Tseng Yu-Hua, Dietrich Arne, Schön Michael R, Kiess Wieland, Stumvoll Michael, Blüher Matthias, Kovacs Peter
Abstract excerpt
OBJECTIVE: Members of the family of bone morphogenetic proteins (BMPs) are important regulators of adipogenesis. We examined the role of the BMP receptor 1A gene (BMPR1A) in the pathophysiology of human obesity. RESEARCH DESIGN AND METHODS: We measured BMPR1A mRNA expression in paired samples of visceral and subcutaneous adipose tissue from 297 subjects and sequenced the BMPR1A in 48 nonrelated white subjects....
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