Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element.

doi:10.1002/jcb.22209

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Article

Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element.

Journal of cellular biochemistry - 15 Aug 2009

Devaney Joseph M, Tosi Laura L, Fritz David T, Gordish-Dressman Heather A, Jiang Shan, Orkunoglu-Suer Funda E, Gordon Andrew H, Harmon Brennan T, Thompson Paul D, Clarkson Priscilla M, Angelopoulos Theodore J, Gordon Paul M, Moyna Niall M, Pescatello Linda S, Visich Paul S, Zoeller Robert F, Brandoli Cinzia, Hoffman Eric P, Rogers Melissa B

Abstract excerpt

A classic morphogen, bone morphogenetic protein 2 (BMP2) regulates the differentiation of pluripotent mesenchymal cells. High BMP2 levels promote osteogenesis or chondrogenesis and low levels promote adipogenesis. BMP2 inhibits myogenesis. Thus, BMP2 synthesis is tightly controlled. Several hundred nucleotides within the 3' untranslated regions of BMP2 genes are conserved from mammals to fishes indicating that...

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Identifiers

PMID: 19492344
DOI: 10.1002/jcb.22209
PMCID: PMC4147943

Genes

BMP2

Variants

rs15705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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