Prospective Studies Exploring the Possible Impact of an ID3 Polymorphism on Changes in Obesity Measures.

doi:10.1002/oby.22109

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Article

Prospective Studies Exploring the Possible Impact of an ID3 Polymorphism on Changes in Obesity Measures.

Obesity (Silver Spring, Md.) - 1 Apr 2018

Svendstrup Mathilde, Appel Emil V R, Sandholt Camilla H, Ahluwalia Tarunveer S, Ängquist Lars H, Thuesen Betina H, Jørgensen Marit E, Pedersen Oluf, Grarup Niels, Hansen Torben, Sørensen Thorkild I A, Vestergaard Henrik

Abstract excerpt

OBJECTIVE: Changes in fat mass depend on adipogenesis and angiogenesis, mechanisms regulated by the inhibitor of differentiation-3 (ID3). Id3 knockout mice showed attenuated increases in BMI and visceral fat mass. We hypothesized that the ID3 missense variant (rs11574-A) would lead to an attenuated increase over time in fat mass, BMI, waist circumference (WC), and waist-hip ratio (WHR) in humans. METHODS: The...

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PMID: 29442437
DOI: 10.1002/oby.22109

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