Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas.

doi:10.1097/PAI.0b013e3181f09179

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Article

Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Mar 2011

Pai Rish K, Mojtahed Kaveh, Pai Reetesh K

Abstract excerpt

The role of gallbladder adenomas in the pathogenesis of gallbladder carcinoma is still controversial. Comparison of the genetic abnormalities seen in adenomas may provide insight into the potential role of gallbladder adenomas as precursor lesions to gallbladder carcinoma. The purpose of this study was to evaluate gallbladder carcinomas, gallbladder adenomas, and high-grade dysplastic lesions for the BRAF and the...

Topics

Adenocarcinoma
Adenoma
Aged
DNA Mismatch Repair
Female
Gallbladder Neoplasms
Humans
Immunohistochemistry
Incidence
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitogen-Activated Protein Kinases

Mutation

Proto-Oncogene Proteins

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Retrospective Studies

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 21307665
DOI: 10.1097/PAI.0b013e3181f09179

Genes

KRAS
BRAF
MLH1
MSH2
MSH6
PMS2

Variants

Provenance

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