Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions.

doi:10.1097/PAS.0b013e3181983ef7

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Article

Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions.

The American journal of surgical pathology - 1 May 2009

Ruemmele Petra, Dietmaier Wolfgang, Terracciano Luigi, Tornillo Luigi, Bataille Frauke, Kaiser Annette, Wuensch Peter-Heinz, Heinmoeller Ernst, Homayounfar Kia, Luettges Jutta, Kloeppel Guenter, Sessa Fausto, Edmonston Tina Bocker, Schneider-Stock Regine, Klinkhammer-Schalke Monika, Pauer Armin, Schick Stefan, Hofstaedter Ferdinand, Baumhoer Daniel, Hartmann Arndt

Abstract excerpt

The prevalence and development of microsatellite instability (MSI) and underlying mismatch repair (MMR) deficiency in the carcinogenesis of adenocarcinomas of the papilla of Vater and their precursor lesions are not well established. We analyzed 120 ampullary adenomas (31 pure adenomas and 89 carcinoma-associated adenomas) and 170 pure adenocarcinomas for MSI, immunohistochemical expression of MMR proteins and...

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PMID: 19252434
DOI: 10.1097/PAS.0b013e3181983ef7

Genes

MLH1
MSH6
MSH2

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