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Article

Histological and genetic changes in malignant transformation of gallbladder adenoma.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jan 1999

Watanabe H, Date K, Itoi T, Matsubayashi H, Yokoyama N, Yamano M, Ajioka Y, Nishikura K

Abstract excerpt

DESIGN: Elucidate the histological and genetic changes in malignant transformation of adenoma of the gallbladder. MATERIALS AND METHODS: Forty-three adenomas and 20 intramucosal tumors of carcinoma-in-adenomas were studied for histological and genetic changes (particularly K-ras mutation and p53 protein overexpression by immunohistochemistry) in malignant transformation. The genetic changes were compared with...

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PMID: 10436806

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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