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Article

Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract - 1 Aug 2009

Schönleben Frank, Qiu Wanglong, Allendorf John D, Chabot John A, Remotti Helen E, Su Gloria H

Abstract excerpt

BACKGROUND: Mutations of KRAS are known to occur in periampullary and ampullary adenomas and carcinomas. However, nothing is known about NRAS, HRAS, BRAF, and PIK3CA mutations in these tumors. While oncogenic BRAF contributes to the tumorigenesis of both pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasms/carcinomas (IPMN/IPMC), PIK3CA mutations were only detected in IPMN/IPMC. This...

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Source

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Identifiers

PMID: 19440799
DOI: 10.1007/s11605-009-0917-4
PMCID: PMC3915027

Genes

BRAF
KRAS
HRAS
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas.PMID 19440799Read ↗

Advances in Molecular Pathology and Treatment of Periampullary Cancers.Semantic proximity Read ↗

Low incidence of KRAS, BRAF, and PIK3CA mutations in adenocarcinomas of the ampulla of Vater and their prognostic value.Semantic proximity Read ↗

Intraductal papillary mucinous neoplasms of the pancreas: Clinical association with KRAS.Semantic proximity Read ↗

Activating mutations of GNAS and KRAS in cystic fluid can help detect intraductal papillary mucinous neoplasms of the pancreas.Semantic proximity Read ↗

BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas.Semantic proximity Read ↗

Mucinous cystic neoplasms of the liver and pancreas: relationship between KRAS driver mutations and disease progression.Semantic proximity Read ↗

GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas.Semantic proximity Read ↗

Molecular aspects of BRAF and HER2 in prognosis of periampullary carcinoma.Semantic proximity Read ↗

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Deep sequencing of cancer-related genes revealed GNAS mutations to be associated with intraductal papillary mucinous neoplasms and its main pancreatic duct dilation.Semantic proximity Read ↗

Integration of KRAS testing in the diagnosis of pancreatic cystic lesions: a clinical experience of 618 pancreatic cysts.Semantic proximity Read ↗

GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "incipient IPMNs".Semantic proximity Read ↗

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