Article
Unraveling innate immunity using large scale N-ethyl-N-nitrosourea mutagenesis.
Tissue antigens - 1 May 2005
Hoebe K, Beutler B
Abstract excerpt
With the mouse genome almost entirely sequenced and readily accessible to all who wish to examine it, the challenge across most biological disciplines now lies in the decipherment of gene and protein function rather than in the realm of gene identification per se. In the field of innate immunity, forward genetic methods have repeatedly been applied to identify key sensors, adapters, and effector molecules....
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