Article
Efficient transcription of the human angiotensin II type 2 receptor gene requires intronic sequence elements.
The Biochemical journal - 15 May 1999
Warnecke C, Willich T, Holzmeister J, Bottari S P, Fleck E, Regitz-Zagrosek V
Abstract excerpt
To investigate mechanisms of human angiotensin II type 2 receptor (hAT2) gene regulation we functionally characterized the promoter and downstream regions of the gene. 5'-Terminal deletion mutants from -1417/+100 to -46/+100 elicited significant but low functional activity in luciferase reporter gene assays with PC12W cells. Inclusion into the promoter constructs of intron 1 and the transcribed region of the hAT2...
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