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Article

Role of Genetic Mutations of the Na+/H+ Exchanger Isoform 1, in Human Disease and Protein Targeting and Activity.

Molecular and cellular biochemistry - 1 Feb 2021

Fliegel Larry

Abstract excerpt

The mammalian Na+/H+ exchanger isoform one (NHE1) is a plasma membrane protein that is ubiquitously present in human cells. It functions to regulate intracellular pH removing an intracellular proton in exchange for one extracellular sodium and is involved in heart disease and in promoting metastasis in cancer. It is made of a 500 amino acid membrane domain plus a 315 amino acid, regulatory cytosolic tail. The...

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Identifiers

PMID: 33201382
DOI: 10.1007/s11010-020-03984-4

Genes

SLC9A1

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