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Article

What we know about the structure of NCX1 and how it relates to its function.

Annals of the New York Academy of Sciences - 1 Mar 2007

Nicoll Debora A, Ren Xiaoyan, Ottolia Michela, Phillips Martin, Paredes Alfredo R, Abramson Jeff, Philipson Kenneth D

Abstract excerpt

NCX1 is modeled to contain nine transmembrane segments (TMS) with a large intracellular loop between TMS 5-6 and two reentrant loops connecting TMS 2-3 and TMS 7-8. NCX1 also contains two regions of internal repeats. The alpha repeats are composed of TMS 2 and 3 and TMS 7 and 8 and are involved in ion binding and transport. The beta repeats are in the large intracellular loop and are involved in binding of...

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PMID: 17303833
DOI: 10.1196/annals.1387.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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