Article
Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.
Genesis (New York, N.Y. : 2000) - 1 Feb 2010
Qiu Min Ru, Jiang Lele, Matthaei Klaus I, Schoenwaelder Simone M, Kuffner Tamara, Mangin Pierre, Joseph Joanne E, Low Joyce, Connor David, Valenzuela Stella M, Curmi Paul M G, Brown Louise J, Mahaut-Smith Martyn, Jackson Shaun P, Breit Samuel N
Abstract excerpt
CLIC1 belongs to a family of highly conserved and widely expressed intracellular chloride ion channel proteins existing in both soluble and membrane integrated forms. To study the physiological and biological role of CLIC1 in vivo, we undertook conditional gene targeting to engineer Clic1 gene knock-out mice. This represents creation of the first gene knock-out of a vertebrate CLIC protein family member. We first...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.