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Article

GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Mookherjee Paramita, Green Pattie S, Watson G Stennis, Marques Marcos A, Tanaka Kohichi, Meeker Kole D, Meabon James S, Li Ning, Zhu Ping, Olson Valerie G, Cook David G

Abstract excerpt

Glutamate transporters regulate normal synaptic network interactions and prevent neurotoxicity by rapidly clearing extracellular glutamate. GLT-1, the dominant glutamate transporter in the cerebral cortex and hippocampus, is significantly reduced in Alzheimer's disease (AD). However, the role GLT-1 loss plays in the cognitive dysfunction and pathology of AD is unknown. To determine the significance of GLT-1...

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Identifiers

PMID: 21677376
DOI: 10.3233/JAD-2011-110503
PMCID: PMC3256092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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