Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intrinsic TNF/TNFR2 interactions fine-tune the CD8 T cell response to respiratory influenza virus infection in mice.

PloS one - 1 Jan 2013

Wortzman Michael E, Lin Gloria H Y, Watts Tania H

Abstract excerpt

TNF is an important inflammatory mediator and a target for intervention. TNF is produced by many cell types and is involved in innate inflammation as well as adaptive immune responses. CD8 T cells produce TNF and can also respond to TNF. Deficiency of TNF or TNFR2 has been shown to affect anti-viral immunity. However, as the complete knockout of TNF or its receptors has effects on multiple cell types as well as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to CD8-Positive T-Lymphocytes
Share to Cell Degranulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Orthomyxoviridae

Share to Orthomyxoviridae Infections

Share to Receptors, Tumor Necrosis Factor, Type II

Share to Respiratory Tract Infections

Share to Tumor Necrosis Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 23874808
DOI: 10.1371/journal.pone.0068911
PMCID: PMC3706430

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intrinsic TNF/TNFR2 interactions fine-tune the CD8 T cell response to respiratory influenza virus infection in mice.PMID 23874808Read ↗

TNF Superfamily Member 14 Drives Post-Influenza Depletion of Alveolar Macrophages Enabling Secondary Pneumococcal PneumoniaSemantic proximity Read ↗

Genomic Profiling of Tumor Necrosis Factor Alpha (TNF-α) Receptor and Interleukin-1 Receptor Knockout Mice Reveals a Link between TNF-α Signaling and Increased Severity of 1918 Pandemic Influenza Virus InfectionSemantic proximity Read ↗

RNF144A shapes the hierarchy of cytokine signaling to provide protective immunity against influenzaSemantic proximity Read ↗

Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virus.Semantic proximity Read ↗

The Significance of Tumor Necrosis Factor Receptor Type II in CD8+ Regulatory T Cells and CD8+ Effector T Cells.Semantic proximity Read ↗

Divergent effects of a Treg-selective IL-2 mutein on Influenza specific T cell responsesSemantic proximity Read ↗

A suitable murine model for studying respiratory coronavirus infection and therapeutic countermeasures in BSL-2 laboratoriesSemantic proximity Read ↗

Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.Semantic proximity Read ↗

Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2 ProteinSemantic proximity Read ↗

Allergic lung inflammation is mediated by soluble tumor necrosis factor (TNF) and attenuated by dominant-negative TNF biologics.Semantic proximity Read ↗

Modulation of Tumor Necrosis Factor by Microbial PathogensSemantic proximity Read ↗

Suppression of Cytotoxic T Cell Functions and Decreased Levels of Tissue Resident Memory T cell During H5N1 infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.