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Article

The biological activity of the prototypic cyclotide kalata b1 is modulated by the formation of multimeric pores.

The Journal of biological chemistry - 31 Jul 2009

Huang Yen-Hua, Colgrave Michelle L, Daly Norelle L, Keleshian Asbed, Martinac Boris, Craik David J

Abstract excerpt

The cyclotides are a large family of circular mini-proteins containing a cystine knot motif. They are expressed in plants as defense-related proteins, with insecticidal activity. Here we investigate their role in membrane interaction and disruption. Kalata B1, a prototypic cyclotide, was found to induce leakage of the self-quenching fluorophore, carboxyfluorescein, from phospholipid vesicles. Alanine-scanning...

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Identifiers

PMID: 19491108
DOI: 10.1074/jbc.M109.003384
PMCID: PMC2742835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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