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Article

The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1.

Nucleic acids research - 1 May 2011

Liang Chung-Yi, Hsu Pang-Hung, Chou Dai-Fang, Pan Chao-Yu, Wang Long-Chi, Huang Wei-Chieh, Tsai Ming-Daw, Lo Wan-Sheng

Abstract excerpt

The dynamics of histone methylation have emerged as an important issue since the identification of histone demethylases. We studied the regulatory function of Rph1/KDM4 (lysine demethylase), a histone H3K36 demethylase, on transcription in Saccharomyces cerevisiae. Overexpression of Rph1 reduced the expression of PHR1 and increased UV sensitivity. The catalytically deficient mutant (H235A) of Rph1 diminished the...

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PMID: 21296759
DOI: 10.1093/nar/gkr040
PMCID: PMC3105397

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