The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1.

doi:10.1093/nar/gkr040

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Article

The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1.

Nucleic acids research - 1 May 2011

Liang Chung-Yi, Hsu Pang-Hung, Chou Dai-Fang, Pan Chao-Yu, Wang Long-Chi, Huang Wei-Chieh, Tsai Ming-Daw, Lo Wan-Sheng

Abstract excerpt

The dynamics of histone methylation have emerged as an important issue since the identification of histone demethylases. We studied the regulatory function of Rph1/KDM4 (lysine demethylase), a histone H3K36 demethylase, on transcription in Saccharomyces cerevisiae. Overexpression of Rph1 reduced the expression of PHR1 and increased UV sensitivity. The catalytically deficient mutant (H235A) of Rph1 diminished the...

Topics

Acetylation
Binding Sites
Cell Cycle Proteins
Checkpoint Kinase 2
Chromatin
DNA Damage
Deoxyribodipyrimidine Photo-Lyase
Gene Expression Regulation, Fungal
Histone Demethylases
Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylation

Mutation

Phosphorylation

Promoter Regions, Genetic

Protein Serine-Threonine Kinases

Repressor Proteins

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

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Identifiers

PMID: 21296759
DOI: 10.1093/nar/gkr040
PMCID: PMC3105397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21296759-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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