Article
Interferon-gamma increases susceptibility of murine pancreatic beta cells to lysis by allogeneic cytotoxic T lymphocytes.
Autoimmunity - 1 Jan 1990
Cearns-Spielman J, Cavender D E, Wood P J
Abstract excerpt
The selective loss of insulin-producing pancreatic beta cells which occurs in IDDM has been postulated to result from lysis by beta cell-specific cytotoxic T lymphocytes (CTL). CTL typically recognise antigen in the context of MHC class I molecules, which are normally present at low levels on bet...
Topics
- Animals
- Antibodies, Monoclonal
- Cell Survival
- Cells, Cultured
- Diabetes Mellitus, Type 1
- Dose-Response Relationship, Drug
- Histocompatibility Antigens Class I
- Interferon-gamma
- Islets of Langerhans
- Mice
- Mice, Inbred Strains
- Phenotype
- T-Lymphocytes, Cytotoxic
- Time Factors