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Article

Genetic changes in tumour microenvironments.

The Journal of pathology - 1 Mar 2011

Campbell Ian, Qiu Wen, Haviv Izhak

Abstract excerpt

Numerous in vitro and in vivo studies have established that carcinoma-associated fibroblasts differ phenotypically from fibroblasts associated with normal tissue but the mechanisms underlying these differences are unclear. Since carcinoma-associated fibroblasts can be propagated in vitro for extended periods and still maintain their cancer-promoting phenotype, some investigators have proposed that they might have...

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Identifiers

PMID: 21294119
DOI: 10.1002/path.2842

Genes

PTEN

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