Article
The use of exfoliative cell samples to map clonal genetic alterations in the oral epithelium of high-risk patients.
Cancer research - 1 Dec 1997
Rosin M P, Epstein J B, Berean K, Durham S, Hay J, Cheng X, Zeng T, Huang Y, Zhang L
Abstract excerpt
Although it is widely accepted that clonal genetic alterations are an essential component of tumor progression, little is known of the distribution of such changes in high-risk lesions or how such clones are altered over time. We explored the feasibility of using exfoliative cells collected by scraping the mucosal surface to detect allelic loss in oral lesions of 22 patients (14 squamous cell carcinomas, 2...
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