Article
Pancreatic cancer associated fibroblasts display normal allelotypes.
Cancer biology & therapy - 1 Jun 2008
Walter Kimberly, Omura Noriyuki, Hong Seung-Mo, Griffith Margaret, Goggins Michael
Abstract excerpt
BACKGROUND: Recent studies have reported widespread copy number alterations and p53 mutations arising in cancer associated stromal cells. The aim of this study was to determine if pancreatic cancer associated fibroblasts display similar genetic alterations. DESIGN: Cancer-associated fibroblast cultures were established from 7 primary pancreatic adenocarcinomas. These fibroblasts and corresponding normal tissues...
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