Article
No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas.
Nature genetics - 1 May 2008
Qiu Wen, Hu Min, Sridhar Anita, Opeskin Ken, Fox Stephen, Shipitsin Michail, Trivett Melanie, Thompson Ella R, Ramakrishna Manasa, Gorringe Kylie L, Polyak Kornelia, Haviv Izhak, Campbell Ian G
Abstract excerpt
There is increasing evidence showing that the stromal cells surrounding cancer epithelial cells, rather than being passive bystanders, might have a role in modifying tumor outgrowth. The molecular basis of this aspect of carcinoma etiology is controversial. Some studies have reported a high frequency of genetic aberrations in carcinoma-associated fibroblasts (CAFs), whereas other studies have reported very low or...
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