A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction.

doi:10.1038/ng1692

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Article

A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction.

Nature genetics - 1 Jan 2006

Helgadottir Anna, Manolescu Andrei, Helgason Agnar, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Gudbjartsson Daniel F, Gretarsdottir Solveig, Magnusson Kristinn P, Gudmundsson Gudmundur, Hicks Andrew, Jonsson Thorlakur, Grant Struan F A, Sainz Jesus, O'Brien Stephen J, Sveinbjornsdottir Sigurlaug, Valdimarsson Einar M, Matthiasson Stefan E, Levey Allan I, Abramson Jerome L, Reilly Murdach P, Vaccarino Viola, Wolfe Megan L, Gudnason Vilmundur, Quyyumi Arshed A, Topol Eric J, Rader Daniel J, Thorgeirsson Gudmundur, Gulcher Jeffrey R, Hakonarson Hakon, Kong Augustine, Stefansson Kari

Abstract excerpt

Variants of the gene ALOX5AP (also known as FLAP) encoding arachidonate 5-lipoxygenase activating protein are known to be associated with risk of myocardial infarction. Here we show that a haplotype (HapK) spanning the LTA4H gene encoding leukotriene A4 hydrolase, a protein in the same biochemica...

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PMID: 16282974
DOI: 10.1038/ng1692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16282974-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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