Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media.

doi:10.1371/journal.pgen.0020149

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Article

Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media.

PLoS genetics - 6 Oct 2006

Parkinson Nicholas, Hardisty-Hughes Rachel E, Tateossian Hilda, Tsai Hsun-Tien, Brooker Debra, Morse Sue, Lalane Zuzanna, MacKenzie Francesca, Fray Martin, Glenister Pete, Woodward Anne-Marie, Polley Sian, Barbaric Ivana, Dear Neil, Hough Tertius A, Hunter A Jackie, Cheeseman Michael T, Brown Steve D M

Abstract excerpt

Otitis media (OM), inflammation of the middle ear, remains the most common cause of hearing impairment in children. It is also the most common cause of surgery in children in the developed world. There is evidence from studies of the human population and mouse models that there is a significant genetic component predisposing to OM, yet nothing is known about the underlying genetic pathways involved in humans. We...

Topics

Amino Acid Sequence
Animals
Chromosome Mapping
Cloning, Molecular
DNA Mutational Analysis
DNA-Binding Proteins
Ear, Middle
Flow Cytometry
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Granulocytes

Lung

MDS1 and EVI1 Complex Locus Protein

Male

Mice

Mice, Inbred BALB C

Mice, Mutant Strains

Molecular Sequence Data

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 17029558
DOI: 10.1371/journal.pgen.0020149
PMCID: PMC1592239

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