Article
Genetic and functional evidence for a role for SLC11A1 in susceptibility to otitis media in early childhood in a Western Australian population.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2013
Rye Marie S, Wiertsema Selma P, Scaman Elizabeth S H, Thornton Ruth, Francis Richard W, Vijayasekaran Shyan, Coates Harvey L, Jamieson Sarra E, Blackwell Jenefer M
Abstract excerpt
Otitis media (OM) is a common disease in early childhood characterised by inflammation of the middle ear. Susceptibility to recurrent acute OM (rAOM; ≥3 episodes AOM in 6 months) and chronic OM with effusion (COME; middle ear effusion ≥3 months) is 40-70% heritable. Three bacterial pathogens commonly associated with OM, Streptococcus pneumoniae (Sp), non-typeable Haemophilus influenzae (NTHi) and Moraxella...
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