Article
Genetic and functional evidence for a locus controlling otitis media at chromosome 10q26.3.
BMC medical genetics - 6 Feb 2014
Rye Marie S, Scaman Elizabeth S H, Thornton Ruth B, Vijayasekaran Shyan, Coates Harvey L, Francis Richard W, Pennell Craig E, Blackwell Jenefer M, Jamieson Sarra E
Abstract excerpt
BACKGROUND: Otitis media (OM) is a common childhood disease characterised by middle ear effusion and inflammation. Susceptibility to recurrent acute OM and chronic OM with effusion is 40-70% heritable. Linkage studies provide evidence for multiple putative OM susceptibility loci. This study attempts to replicate these linkages in a Western Australian (WA) population, and to identify the etiological gene(s) in a...
Topics
- Child, Preschool
- Chromosome Mapping
- Chromosomes, Human, Pair 10
- Computational Biology
- Female
- Genetic Linkage
- Genetic Loci
- Humans
- Male
- Otitis Media
- Pedigree