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Article

The development and anatomy of the gubernaculum in Hoxa11 knockout mice.

Journal of pediatric surgery - 1 Feb 2011

Nagraj Shobhana, Seah Gloria J, Farmer Pamela J, Davies Ben, Southwell Bridget, Lewis Alfor G, Hutson John M

Abstract excerpt

BACKGROUND: The gubernaculum is central to testicular descent, with recent evidence suggesting that it elongates to the scrotum like a limb bud. Homeobox (Hox) genes involved in limb bud outgrowth are expressed within the gubernaculum. Mice with homozygous Hoxa11 gene deletions have bilateral cryptorchidism. This study investigated the precise anatomical effects of Hoxa11 mutation on the mouse gubernaculum....

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Source

Identifiers

PMID: 21292093
DOI: 10.1016/j.jpedsurg.2010.11.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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