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Article

Cryptorchidism in Mice with an Androgen Receptor Ablation in Gubernaculum Testis

10 Feb 2012

Abstract excerpt

Androgens play a critical role in the development of the male reproductive system, including the positioning of the gonads. It is not clear, however, which developmental processes are influenced by androgens and what are the target tissues and cells mediating androgen signaling during testicular descent. Using a Cre-loxP approach, we have produced male mice (GU-ARKO) with conditional inactivation of the androgen...

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PMID: 22322597
DOI: 10.1210/me.2011-1283

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