Article
Loss of Insl3: a potential predisposing factor for testicular torsion.
The Journal of urology - 1 Jun 2010
Sozubir Selami, Barber Theodore, Wang Yi, Ahn Chul, Zhang Shaohua, Verma Sunita, Lonergan Devin, Lorenzo Armando J, Nef Serge, Baker Linda A
Abstract excerpt
PURPOSE: The testicular hormone Insl3 is critical for mouse gubernacular development. Knockout mice exhibit bilateral intra-abdominal cryptorchidism with absent gubernaculum. Prior studies described torsion of the vas deferens in Insl3 mutant mice. We performed a detailed anatomical analysis of the vas deferens and testis in Insl3 mutant mice to characterize associated anomalies further. MATERIALS AND METHODS:...
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