Learning monotonic genotype-phenotype maps.

Abstract excerpt

Evolutionary escape of pathogens from the selective pressure of immune responses and from medical interventions is driven by the accumulation of mutations. We introduce a statistical model for jointly estimating the dynamics and dependencies among genetic alterations and the associated phenotypic changes. The model integrates conjunctive Bayesian networks, which define a partial order on the occurrences of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Bayes Theorem
• Share to Computer Simulation