What can we learn from fitness landscapes?

Abstract excerpt

A combinatorially complete data set consists of studies of all possible combinations of a set of mutant sites in a gene or mutant alleles in a genome. Among the most robust conclusions from these studies is that epistasis between beneficial mutations often shows a pattern of diminishing returns, in which favorable mutations are less fit when combined than would be expected. Another robust inference is that the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adaptation, Biological
• Share to Alleles
• Share to Bacteria