Article
Learning multiple evolutionary pathways from cross-sectional data.
Journal of computational biology : a journal of computational molecular cell biology - 1 Jan 2000
Beerenwinkel Niko, Rahnenführer Jörg, Däumer Martin, Hoffmann Daniel, Kaiser Rolf, Selbig Joachim, Lengauer Thomas
Abstract excerpt
We introduce a mixture model of trees to describe evolutionary processes that are characterized by the ordered accumulation of permanent genetic changes. The basic building block of the model is a directed weighted tree that generates a probability distribution on the set of all patterns of genet...
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