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Article

Modelled in vivo HIV fitness under drug selective pressure and estimated genetic barrier towards resistance are predictive for virological response.

Antiviral therapy - 1 Jan 2008

Deforche Koen, Cozzi-Lepri Alessandro, Theys Kristof, Clotet Bonaventura, Camacho Ricardo J, Kjaer Jesper, Van Laethem Kristel, Phillips Andrew, Moreau Yves, Lundgren Jens D, Vandamme Anne-Mieke

Abstract excerpt

BACKGROUND: A method has been developed to estimate a fitness landscape experienced by HIV-1 under treatment selective pressure as a function of the genotypic sequence thereby also estimating the genetic barrier to resistance. METHODS: We evaluated the performance of two estimated fitness landscapes (nelfinavir [NFV] and zidovudine [AZT] plus lamivudine [3TC]) to predict week 12 viral load (VL) change for 176...

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PMID: 18572753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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