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Article

Myeloid-Derived Suppressor Cells in Prostate Cancer: Present Knowledge and Future Perspectives.

Cells - 22 Dec 2021

Koinis Filippos, Xagara Anastasia, Chantzara Evangelia, Leontopoulou Vassiliki, Aidarinis Chrissovalantis, Kotsakis Athanasios

Abstract excerpt

Several lines of research are being investigated to better understand mechanisms implicated in response or resistance to immune checkpoint blockade in prostate cancer (PCa). Myeloid-derived suppressor cells (MDSCs) have emerged as a major mediator of immunosuppression in the tumor microenvironment that promotes progression of various tumor types. The main mechanisms underlying MDSC-induced immunosuppression are...

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Identifiers

PMID: 35011582
DOI: 10.3390/cells11010020
PMCID: PMC8750906

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