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Article

Dnmt3a restrains mast cell inflammatory responses.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2017

Leoni Cristina, Montagner Sara, Rinaldi Andrea, Bertoni Francesco, Polletti Sara, Balestrieri Chiara, Monticelli Silvia

Abstract excerpt

DNA methylation and specifically the DNA methyltransferase enzyme DNMT3A are involved in the pathogenesis of a variety of hematological diseases and in regulating the function of immune cells. Although altered DNA methylation patterns and mutations in DNMT3A correlate with mast cell proliferative disorders in humans, the role of DNA methylation in mast cell biology is not understood. By using mast cells lacking...

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Source

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Identifiers

PMID: 28167789
DOI: 10.1073/pnas.1616420114
PMCID: PMC5338402

Genes

IQGAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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