Article
SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity supporting a pro-inflammatory microenvironment.
Cell death & disease - 20 Sept 2023
Molfetta Rosa, Lecce Mario, Milito Nadia D, Putro Erisa, Pietropaolo Giuseppe, Marangio Caterina, Scarno Gianluca, Moretti Marta, De Smaele Enrico, Santini Tiziana, Bernardini Giovanni, Sciumè Giuseppe, Santoni Angela, Paolini Rossella
Abstract excerpt
Mast cells (MCs) are multifaceted innate immune cells often present in the tumor microenvironment (TME). Several recent findings support their contribution to the transition from chronic inflammation to cancer. However, MC-derived mediators can either favor tumor progression, inducing the spread of the tumor, or exert anti-tumorigenic functions, limiting tumor growth. This apparent controversial role likely...
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