Article
Mannose-binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis.
Arthritis research & therapy - 31 Jan 2011
van de Geijn Fleur E, de Man Yaël A, Wuhrer Manfred, Willemsen Sten P, Deelder André M, Hazes Johanna M W, Dolhain Radboud J E M
Abstract excerpt
INTRODUCTION: Rheumatoid arthritis (RA) improves during pregnancy and flares after delivery. It has been hypothesized that high levels of the complement factor mannose-binding lectin (MBL) are associated with a favourable disease course of RA by facilitating the clearance of pathogenic immunoglobulin G (IgG) lacking galactose sugar moieties. During pregnancy, increased galactosylation of IgG and simultaneously...
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