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Article

Association between selected folate pathway polymorphisms and nonsyndromic limb reduction defects: a case-parental analysis.

Paediatric and perinatal epidemiology - 1 Mar 2011

Cleves Mario A, Hobbs Charlotte A, Zhao Weizhi, Krakowiak Patrycja A, MacLeod Stewart L

Abstract excerpt

Inadequate folate status resulting from either genetic variation or nutritional deficiencies has been associated with an increased risk of congenital malformations including orofacial clefting, limb, cardiac and neural tube defects. Few epidemiological studies have examined the association between limb reduction defects (LRDs) and folate-related genetic polymorphisms other than MTHFR 677C→T. We conducted a...

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Source

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Identifiers

PMID: 21281325
DOI: 10.1111/j.1365-3016.2010.01160.x
PMCID: PMC3050483

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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