Article
XRCC1 and ERCC1 variants modify malignant mesothelioma risk: a case-control study.
Mutation research - 15 Mar 2011
Betti M, Ferrante D, Padoan M, Guarrera S, Giordano M, Aspesi A, Mirabelli D, Casadio C, Ardissone F, Ruffini E, Betta P G, Libener R, Guaschino R, Matullo G, Piccolini E, Magnani C, Dianzani I
Abstract excerpt
Malignant pleural mesothelioma (MPM) is a rare aggressive tumor associated with asbestos exposure. The possible role of genetic factors has also been suggested and MPM has been associated with single nucleotide polymorphisms (SNPs) of xenobiotic and oxidative metabolism enzymes. We have identified an association of the DNA repair gene XRCC1 with MPM in the population of Casale Monferrato, a town exposed to high...
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