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Article

Glutamate cysteine ligase (GCL) and self reported depression: an association study from the HUNT.

Journal of affective disorders - 1 Jun 2011

Berk Michael, Johansson Stefan, Wray Naomi R, Williams Lana, Olsson Craig, Haavik Jan, Bjerkeset Ottar

Abstract excerpt

BACKGROUND: There is increasing evidence suggesting oxidative stress may play a role in the aetiology of depression. Glutathione is the brain's predominant free radical scavenger, and associated polymorphisms of the glutamate cysteine ligase (GCL) gene have been reported for related psychiatric disorders. The aim of the study was to investigate candidate polymorphisms of GCL validated in schizophrenia and their...

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Source

Identifiers

PMID: 21277635
DOI: 10.1016/j.jad.2010.12.019

Genes

GCLC
GCLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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