Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lung function loss, smoking, vitamin C intake, and polymorphisms of the glutamate-cysteine ligase genes.

American journal of respiratory and critical care medicine - 1 Jul 2008

Siedlinski Mateusz, Postma Dirkje S, van Diemen Cleo C, Blokstra Anneke, Smit Henriette A, Boezen H Marike

Abstract excerpt

RATIONALE: Smoking-induced oxidative stress contributes to chronic obstructive pulmonary disease, a lung disease characterized by low lung function and increasing mortality worldwide. The counterbalance for this effect may be provided by, for example, increased intake of the antioxidant vitamin C or endogenously acting antioxidant enzymes like glutamate-cysteine ligase (GCL), which is responsible for glutathione...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidants
Share to Ascorbic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forced Expiratory Volume

Share to Glutamate-Cysteine Ligase

Share to Oxidative Stress

Share to Pulmonary Disease, Chronic Obstructive

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 18420959
DOI: 10.1164/rccm.200711-1749OC

Genes

GCLC
FEV
TNR
GCLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lung function loss, smoking, vitamin C intake, and polymorphisms of the glutamate-cysteine ligase genes.PMID 18420959Read ↗

Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease.Semantic proximity Read ↗

A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers.Semantic proximity Read ↗

Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function.Semantic proximity Read ↗

[The relationship between the polymorphism of glutamate cysteine ligase modulatory subunit gene and the susceptibility to chronic obstructive pulmonary disease].Semantic proximity Read ↗

Genetic variants associated with the risk of chronic obstructive pulmonary disease with and without lung cancer.Semantic proximity Read ↗

Genetic interaction of GSH metabolic pathway genes in cystic fibrosis.Semantic proximity Read ↗

Chronic beryllium disease and glutathione biosynthesis genes.Semantic proximity Read ↗

Genetic variation and gene expression in antioxidant related enzymes and risk of COPD: a systematic reviewSemantic proximity Read ↗

Polymorphism of Glutamate-Cysteine Ligase Subunit Catalytic (GCLC) Gene in Pulmonary Tuberculosis Patients.Semantic proximity Read ↗

Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growth.Semantic proximity Read ↗

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.Semantic proximity Read ↗

Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.