Article
Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study.
The American journal of clinical nutrition - 1 Aug 2007
Halsted Charles H, Wong Donna H, Peerson Janet M, Warden Craig H, Refsum Helga, Smith A David, Nygård Ottar K, Ueland Per M, Vollset Stein E, Tell Grethe S
Abstract excerpt
BACKGROUND: Glutamate carboxypeptidase II (GCPII) encodes for intestinal folate hydrolase and brain N-acetylated alpha-linked acidic dipeptidase. Previous studies provided conflicting results on the effect of the GCPII 1561C-->T polymorphism on folate and total homocysteine (tHcy) concentrations. OBJECTIVE: We aimed to determine the potential effects of 2 polymorphisms of GCPII on plasma folate and tHcy...
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